I liked Lexie but she was criminally underused and wasted in unnecessary romantic storylines. Her conflict with Bailey over the chief resident position was interesting at first but then went nowhere, since she was less interested in work than in her messy personal life. The actress had the most chemistry with other male actors, aside from George. I never bought Callie turning into a pussy lover. Should stay being an ass or run away with Addison. Mark was a one-dimensional character and I found his change from a sleazy manwhore to a dutiful family man contrived. He worked the best as a friend to Meredith and Izzie, not someone who is crushing on either of them. They could go with the classic 'coming out against parental pressure' storyline. George should have been written as gay from the start. Izzie was the best snarking with Alex and Yang or standing up to herself and being a badass doctor than crying her eyes out because of another man not loving her and/or dying. The patient Denny storyline should have never happened or ended differently. Heigl and Oh had the best comedic timings and could handle dramatic storylines as well. Out of all characters, I liked Yang, Izzie and Owen the most. I'm sure a new viewer would assume that Mark Sloane was a loving and kind man, as well as supremely professional. I would say he got the best death in the history of the show. I appreciated Mark's humor in the later seasons, but his death was so over the top. Even Donald Trump adores his daughter (at least one of them).
He's a huge misogynist asshole and he probably wouldn't ever change, he would have simply made an exception with Sofia. I hate that he shamed Rose into having sex with Derek. I strongly disliked him when he came on the show. Too bad Lexie didn't break his penis for good. And let's not forget that he knocks up Callie during casual sex.
In fact, he's the biggest whore in the history of the show. Apparently Mark wants the party to be huge, and points out - this isn't a baby shower for some nurse who can't keep her knees together. I just watched the episode when they're planning a goodbye party for Callie and Arizona. I thought I'd gotten over the Mark hate because of his love for Sofia.